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Carbon Monoxide Poisoning

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Table 3. Prenatal CO Exposures - Animal Studies - Behavioral Effects:

Species Carbon Monoxide Exposure Effects
mouse lower level CO, throughout gestation increased errors in heat-motivated maze
mouse low to moderate level CO, many days impaired righting reflex & impaired negative geotaxis
rat moderate level CO, throughout gestation decreased birth wt., decreased pre-weaning wts., decreased locomotor responses to L-dopa in open field,
increased rate of habituation
rat moderate level CO, throughout gestation decreased birth wt., decreased pre-weaning wt., decreased negative geotaxis, decreased homing behavior
rat high level CO, few hours, one day only increased exploratory activity in maze
rat moderate level CO, throughout gestation decreased acquisition & 24-hour retention of 2-way active avoidance
rat high level CO, 81 minutes x 2, throughout gestation appearance of upper and lower incisors delayed, 1 day delay of righting reflex, free-fall righting & negative geotaxis
rat moderate level CO, throughout gestation decreased minimal frequency of ultrasonic calls by pups removed from nest,
decreased responsiveness to a challenge dose of diazepam, alterations in acquisition of an avoidance task
pig moderate-high level CO, part of gestation longer to suckle the first time, decreased performance tests of ability to orient, maneuver to investigate environment


Note: For more detailed information, contact the webmaster (E-mail = dpenney@cmb.biosci.wayne.edu), or consult the book Carbon Monoxide, 1996, by David G. Penney, Ph.D.


...... last changed 07/01/02



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